The “Statistical Design Support System” produces a new practical optimal design method. It can be used even on nonlinear behavior. The optimization can be carried out with this system using a small number of calculation results. The authors applied it to the design optimization of the occupant restraint system in order to reduce the injury criteria based on the crash simulation. In line with growing interest and improvements in technology on vehicle safety, it will be necessary to consider some different crash situations simultaneously. The authors made an optimal design taking into account the different collision conditions. This paper describes the effectivity analysis and the optimization.