The challenge of designing next-generation systems that meet goals for system effectiveness, environmental compatibility, and cost has grown to the point that traditional design methodologies are becoming ineffective. Increases in the analysis complexity required, the number of objectives and constraints to be evaluated, and the multitude of uncertainties in today’s design problems are primary drivers of this situation. A new environment for design has been formulated to treat this situation. It is viewed as a testbed, in which new techniques in such areas as design-oriented/physics-based analysis, uncertainty modeling, technology forecasting, system synthesis, and decision-making can be posed as hypotheses. Several recent advances in elements of this multidisciplinary environment, termed the Virtual Stochastic Life Cycle Design Environment, are summarized in this paper.