A closed-loop comprehensive evaluation and a test method for vehicle handling and stability have been studied by using development driving simulator. Simulator test scheme has been designed and carried out with 14 vehicle configurations, and subjective evaluation has been made for easy handling of vehicle by drivers. A closed-loop comprehensive evaluation index has been put forward considering the factors affecting vehicle handling and stability. The reliability of the index has been validated by driver's subjective evaluation. A driver/vehicle/ road closed-loop system model has been established, and the theoretical predictive evaluation has been carried out with 14 vehicle configurations. Simulation showed that similar result for both theoretical predictive evaluation and subjective evaluation.