The fluid flow in a direct-injection gasoline diaphragm fuel pump is analyzed using a multi-physics simulation program. The analysis accounts for fully coupled fluid-structure interactions (FSI), the effects of the diaphragm movement and its deformation, the FSI between the diaphragm and the fluid, the FSI between the inlet/outlet valves and the fluid, and the solid-solid contact between the inlet/outlet valves and the valve seats. The flow rate of the fuel pump under various cam speeds is examined. The accuracy of the predictions for the flow rate of the fuel pump is assessed through comparisons with the experimental data, and moderately good agreement is obtained. In addition, some conclusions based on this study are summarized for reference.