The advent of low emission regulations on fuel systems has made conventional sealing materials such as acry-lonitrile butadiene rubber (NBR) unfit for sealing most fuel systems. Therefore, it is imperative to look beyond conventional rubbers and towards more exotic materials to seal such applications. In this study, the permeation characteristics and the change in physical properties of several elastomeric materials (NBR, hydrogenated NBR (HNBR), and fluorocarbon elastomers (FKM)) as well as various poly(tetrafluoroethylene) (PTFE) composites were evaluated with four different fuel mixtures. The sealing materials were tested using vaporimeter cups. The results are discussed as a function of the materials' nature, composition, and filler content.