In the North American automotive market, cylinder deactivation by means of engine valve deactivation is becoming a significant enabler in reducing the Brake Specific Fuel Consumption (BSFC) of large displacement engines. This allows for the continued market competitiveness of large displacement spark ignition (SI) engines that provide exceptional performance with reduced fuel consumption. As an alternative to a major engine redesign, the Active Fuel Management™ (AFM™) system is a lower cost and effective technology that provides improved fuel economy during part-load conditions. Cylinder deactivation is made possible by utilizing innovative new base engine hardware in conjunction with an advanced control system. In the GM 3.9L V-6 Over Head Valve (OHV) engine, the standard hydraulic roller lifters on the engine's right bank are replaced with deactivating hydraulic roller lifters and a manifold assembly of oil control solenoids. This paper presents the engine hardware modifications and packaging challenges of adapting the AFM™ system to the 3.9L V-6 engine. Finally, fuel economy results for the 2007 3.9L V-6 engine equipped with AFM™ are compared to the fuel economy of its 2006 non-AFM™ predecessor.