Efficient integration of mechanics and microelectronics components is nowadays a must within the automotive industry in order to minimize integration risks and support optimization of the entire system. We propose in this work a cross domain co-simulation platform for the efficient analysis of mechatronic systems. The interfacing of two state-of-the-art simulation platforms provides a direct link between the two domains at an early development stage, thus enabling the validation and optimization of the system already during modeling phase. The proposed cross-domain co-simulation is used within our TEODACS project for the analysis of the FlexRay technology. We illustrate using a drive-by-wire use case how the different architecture choices may influence the system.