The integration of a HIL system involves many software and hardware elements. During the integration process, various errors may occur. In this paper, the Design For Six Sigma (DFSS) methodology is applied to develop an integration process for a generic type of HIL system. The development follows the DCOV (Design, Characterize, Optimize and Verify) four-phase approach. The result is an efficient process proven to meet the customer's needs, reduce integration errors and deliver a high quality HIL system within less time.