During the past years, there has been an increasing tendency to seriously question and break up old and ingrained structures in combustion engine testing. The reason for this is the continuously increasing number of engine and vehicle variants and a variety of applications resulting from it, which significantly push up development costs and times when carrying out the classical testing patterns. The following article by FEV Motorentechnik GmbH introduces a comprehensive test methodology for purposeful endurance testing of modern drive units (in particular from the fields of passenger cars and commercial vehicles). The procedure and the testing philosophy are explained in detail, illustrated by a concrete development example. The result is the FEV MASTER Programme as an advanced testing methodology which is purposefully geared to deal with all aspects of the many application variants while keeping the testing duration short and the number of test subjects small in order to avoid increasing total development costs and periods.