Large eddy simulation based on high-performance computing technique was conducted to investigate the unsteady aerodynamic forces acting on a full-scale heavy duty truck subjected to sudden crosswind. The CFD results were applied to evaluate the effect of the unsteady external forces on a vehicle motion, as a first step toward a more reliable vehicle motion analysis. As the first report, the numerical method was validated on the DNW wind-tunnel data by comparing the time-averaged drag and lateral forces at various yawing angles up to 10 degrees. Then the method was applied to the case when the vehicle goes through the crosswind region. The time series of the aerodynamic forces were acquired and discussed through the visualization of instantaneous flow structures around the vehicle. It was observed that drastic undershooting and overshooting of the yawing moment acts on the vehicle during the rushing in and out process. A simplified model was developed for the long-term motion analysis study to save the computational resources consumed to reproduce the detailed geometry.