The objective of this research is to investigate the effect of the blast load on the vehicle and occupant and identify the sensitivity of the vehicle parameters to the blast load, therefore figure out the design solution to protect the vehicle and occupant. CAE explicit commercial code, LSDYNA, is applied in this research with adopting CONWEP method for the blast load. The LSDYNA 95th percentile Hybrid III dummy model is used for occupant simulation. Seat, seat belt, and underbody and underbody armor are interested areas in the design to meet the survivability and weight target. The results show the protection can be effectively achieved through employing the new design method in three areas mentioned above.