This paper presents the latest development of authors' work on multiple-cylinder engine CFD simulation using Ricardo's engine-focused commercial CFD code, VECTIS. The detailed chemistry-based Ignition Progress Variable Library (IPV-Library) approach has been used for combustion modelling. The simulation is performed on a 4-cylinder in-line Diesel engine, covering the processes of intake, compression, spray, combustion and exhaust. The cyclically converged solution is compared to the engine test data. With a detailed chemistry-based combustion modelling scheme, the approach has the capability to cover a broader range of operating conditions and also different types of engine combustion. Additionally, in terms of computational cost, the use of a combustion reaction library in the framework of cell-based CFD analysis ensures great efficiency. It has been demonstrated by this work that multiple-cylinder engine CFD simulation with detailed chemistry-based combustion modelling can be achieved with VECTIS on an affordable time scale and computational cost.