The fastener analysis for an airframe panels under random cyclic loading conditions were analyzed with various elaborate solutions. But here a simple technique is proposed to analyze the problem and prove the necessity for a design solution. It is shown that the misfit in the fastener system reduces the load capacity of the joint due to the lack of contact or reduced contact. This reduced contact also produces various stress concentration at the contact zones. In the cyclic loading environment this reduced load capacity and increased stress concentration produces elastic plastic deformation around the contact locations and at the same time a crack develops and propagates beyond the fastener system. This creates a load leak transparent to the fastener system. Thus the misfit fastener systems have a higher probability of aging than the fit fasteners. With the proof in hand various design patterns were proposed to improve the fatigue characters under varying types of loading conditions.