Once limited by insufficient accuracy, the off-the-shelf industrial robot has been enhanced via the integration of secondary encoders at the output of each of its axes. This in turn with a solid mechanical platform and enhanced kinematic model enable on-part accuracies of less than +/−0.25mm. Continued development of this enabling technology has been demonstrated on representative surfaces of an aircraft fuselage. Positional accuracy and process capability was validated in multiple orientations both in upper surface (spindle down) and lower surface (spindle up) configurations. A second opposing accurate robotic drilling system and full-scale fuselage mockup were integrated to simulate doubled throughput and to demonstrate the feasibility of maintaining high on-part accuracy with a dual spindle cell.