The performance of an EGR cooler is influenced significantly by particulate fouling in the cooler. As a result of fouling, a highly porous soot deposit layer is formed in the EGR cooler. This deposit layer not only causes a decrease in the cooler effectiveness but also an increase in the EGR pressure drop over the cooler. Increasing the EGR cooler pressure drop reduces the driving force for the EGR flow under a given differential pressure across the engine. Thus, the EGR cooler fouling has a big impact on the control of the engine-out NO emissions. In this paper, a semi-empirical model is developed for predicting pressure drops of fouled EGR coolers. Based on this model and the particulate fouling model developed previously by the author, the process is analyzed for the pressure drop increase with building up of the soot deposit in an EGR cooler. The predicted pressure drops for the fouled coolers agree well with the experimental data for both tube-winglet type and tube-fin type EGR coolers.