A new inter-disciplinary degree program has been developed at Lawrence Technological University: the Master of Science in Mechatronic Systems Engineering Degree (MS/MSE). It is one of a few MS-programs in mechatronics in the U.S.A. today.This inter-disciplinary program reflects the main areas of ground vehicle mechatronic systems and robotics. This paper presents areas of scientific and technological principles which the Mechanical Engineering, Electrical and Computer Engineering, and Math and Computer Science Departments bring to Mechatronic Systems Engineering and the new degree program. New foundations that make the basis for the program are discussed.One of the biggest challenges was developing foundations for mechanical engineering in mechatronic systems design and teaching them to engineers who have different professional backgrounds. The authors first developed new approaches and principles to designing mechanical subsystems as components of mechatronic systems. Then, the developed principles and approaches were implemented in the MS/MSE program curriculum which consists of three course modules (eight core courses).The MS/MSE program and a new Research Laboratory of Mechatronic Systems were developed with support and collaboration of industry. The paper discusses aspects of collaboration with the private companies and development of new educational approaches to learning commercial software/hardware for designing mechanical subsystems and making this process a part of the mechatronics laboratory development.