Hybrid high voltage battery pack is not only heavy mass but also large in dimension. It interacts with the vehicle through the battery tray. Thus the battery tray is a critical element of the battery pack that interfaces between the battery and the vehicle, including the performances of safety/crash, NVH (modal), and durability. The tray is the largest and strongest structure in the battery pack holding the battery sections and other components including the battery disconnect unit (BDU) and other units that are not negligible in mass. This paper describes the mass optimization work done on one of the hybrid batteries using CAE simulation. This was a multidisciplinary optimization project, in which modal performance and fatigue damage were accessed through CAE analysis at both the battery pack level, and at the vehicle level. The final battery tray design based on CAE analysis results and recommendations was validated through physical vehicle tests, and implemented into the vehicle production.