This paper presents a control system development for a yaw motion control of a vehicle-trailer combination using the integrated control of active front steer (AFS) and differential brake (DB). A 21 degree of freedom (dof) vehicle-trailer combination model that represents a large SUV and a medium one-axle trailer has been developed for this study. A model reference sliding mode controller (MRSMC) has been developed to generate the desired yaw moment. Based on the understanding of advantages and limitations of AFS and DB, a new integrated control algorithm was proposed. The simulation result shows that integrated control of AFS and DB can restrain the trailer's oscillation effectively and shows less longitudinal speed drop and higher stable margin compared to the DB activated only case while maintaining the yaw stability.