The objective of this study is to obtain a strategy for adapting injection and exhaust gas recirculation (EGR) conditions to various engine speeds. An experimental study was conducted using a single-cylinder test engine and varying the injection timings of two-stage injection, the injection-quantity ratio, the EGR rate, and the swirl ratio at low (1300 rpm) and high (2300 rpm) engine speeds. When using base injection conditions, the results indicated that problems occurred for the high maximum pressure rise rate at low engine speed and the low thermal efficiency at high engine speed. At low engine speed, retarding the injection timings and increasing the first-injection quantity ratio reduced the maximum pressure rise rate without sacrificing engine performance. At high engine speed, advancing the injection timings improved the thermal efficiency but increased smoke emission. In addition to advancing the injection timings, a decrease of the first-injection quantity ratio reduced smoke emission.