From current point of view future emission legislations for heavy-duty engines as well as industrial engines will require complex engine internal measures in combination with sophisticated aftertreatment systems as well as according control strategies to reach the emission targets. With EU VI, JP 09/NLT and US10 for heavy-duty engines as well as future Tier4 final or stage IV emission legislation for industrial applications, EGR + DPF + SCR probably will be combined for most applications and therefore quite similar technological approaches will be followed up in Europe as well as in the US and in Japan.Most “emerging markets” all over the world follow up the European, US or Japanese emission legislation with a certain time delay. Therefore similar technologies need to be introduced in these markets in the future. On the other hand specific market boundary conditions and requirements have to be considered for the development of tailored system concepts in these markets. This includes e.g. cost aspects as well as specific climate conditions. Another very important factor will be the fuel quality, which has to be expected in these markets. For example, the cetane number might significantly impact the combustion behaviour, bio fuel content carefully has to be considered with regard to base engine as well as aftertreatment system performance and fuel sulfur content especially has to be judged as critical with regard to the aftertreatment system.Within this paper the impact of fuel quality aspects especially including cetane number, bio fuel content and fuel sulfur content on base engine behaviour as well as aftertreatment performance will be discussed and according approaches in order to take the variety of fuel qualities for different markets into account will be pointed out. Within this context e.g. active desulfation modes as well as closed-loop cylinder pressure control strategies will be considered.