A finite diffusion method is presented in this paper to model droplet evaporation for complex liquid mixture composed of different homogeneous groups. Multiple components fuel mixture is represented by separate distribution functions to describe the composition of each homogeneous group in the mixture. Only a few parameters are required to describe the mixture. Quasi-steady assumption is applied in the determination of evaporation rates and heat flux to the droplet, and the effects of surface regression, finite diffusion and preferential vaporization of the mixture are included in the liquid phase equations using an effective properties approach. The proposed model was validated by comparing against experimental measurements for single, isolated droplets of n-decane, kerosene, heptane-decane and diesel-butanol. The present model was applied to simulate the evaporation of isolated droplets with composition of typical diesel. Computations showed that the model captured the main distillation characteristics of commercial fuels reasonably well. The proposed model is capable in capturing the vaporization characteristics of complex liquid mixtures.