High-powered vehicles offer an advantage of superior fuel economy through use of regenerative braking and lowered transient emissions by reducing the operating portion of the engine to follow load as closely as in a conventional bus. A hybrid bus was designed and a prototype was developed. It has a parallel-type hybrid powertrain system and uses a 6-liter diesel engine which satisfy Euro-5 emission standard. 44-kW-electric motor, AMT (automated manual transmission) and Li-ion-type batteries were applied to this hybrid bus.Total 8 hybrid buses are test-running in 6 cities and the driving performances are monitored in terms of fuel efficiency, emission and convenience. This paper presents the performance, major component features and calibration procedures of hybrid powertrain systems. Test run monitoring result showed a benefit of fuel economy at least 36% by comparing to a conventional diesel-powered bus. Chassis dynamometer tests were also carried out and hybrid bus showed 42% ~ 54% higher fuel efficiency and low emission levels than diesel bus. So it is expected that this system may become a cost-effective alternative drive for next medium and heavy hybrid vehicles.