The automotive weather strip performs functions of isolating water, dust, noise and vibration from the outside. To achieve good sealing performance, weather strip should be designed to have the high contact force and wide contact area. The compression load of weather strip is important for closing force in initial quality, but the permanent deformation is used to predict influx of wind noise over long periods of time. To check these accurately and easily, a new test method is demanded.So this paper introduces a new test method to predict the compression load and permanent deformation of 3D full vehicle by using ABAQUS. Uniaxial tension and creep tests were conducted to obtain the material data. The lab test for the permanent deformation was accelerated at high temperature during shorter time of 300 hours.Herein Proposed test method can provide accurate prediction under the different loading conditions and section shapes, and will also save time and cost.