In the current scenario of growing demand for lightweight designs for improving fuel economy and reduced cost, the focus is on optimum design solutions. This calls for improved and accurate prediction capabilities in terms of life or cycles the design can sustain in real world usage profile. Conventionally, the differential casings are simulated and designed for worst loads experienced and the approach used is infinite life design for these loads. But, this would lead to overdesign and increase weight. To counter this problem the methodology for fatigue analysis for the derived duty cycle of differential casing is developed. The critical regions can be identified based on life and the solutions can be worked out without major design changes.This paper briefs the nonlinear static load cases required for deriving the block cycle loading and incorporating these as a duty cycle in fatigue solver. This results in identifying critical regions based on fatigue life using quasi static fatigue approach.