A fuel cell system consists of a stack, a hydrogen fuel supply and an air supply system. This provides the required air flow and pressure which allows the stack to properly react on the cathode side to recombine Oxygen with the Hydrogen's protons and electrons resulting in water and heat. In addition the air flow and pressure are supporting directly or indirectly the water management. In this paper different air supply systems for automotive application developed by NuCellSys are compared: screw compressor and electrical turbo charger. Different technologies and control strategies allow the fuel cell system integrator to find the optimum between performances, weight, volume and cost. The authors describe the challenges and the new frontier of air supply systems for automotive fuel cell system application.