In order to improve ride comfort and reduce interior noise of commercial vehicles, modal sensitivity analysis and optimization design of a commercial vehicle cab was carried out, which increased the first natural frequency of the optimized cab by 23.96%. The result of cab modal test verified the correctness of the finite element model and the effectiveness of the improving method. The structure-acoustic coupling model of the cab was established, and the acoustic response of the coupled sound field was predicted. The sound pressure level of the optimized cab was reduced. In comparison of the optimized cab with the original one, the optimization scheme was confirmed to be effective and reasonable.