This paper provides an investigation to improve vehicle powertrain NVH performance via modification of excitation and radiation system of powertrain. First of all, considering different excitation mechanisms of the powertrain, the excitation forces are analyzed. The FEM/BEM coupled analysis and the acoustic transfer vector (ATV) calculation as well as panel contribution analysis are applied to investigating the acoustic characteristics of the powertrain. Then a hybrid approach which couples the transmission gear profile modification for attenuating gear system excitation and the transmission housing modification for reducing transmission housing noise radiation is proposed to improve powertrain NVH performance. Experiment validation is conducted in order to assess the modified results. The assessment shows that this hybrid approach can effectively predict and reduce powertrain noise and vibration.