Torsional vibration of drive shaft has great influence on the vibration of vehicle. Reasonable phase arrangement of multi-universal coupling can attenuate vibration. In this paper, theoretical model of drive shaft with planar multi-cross universal coupling was established; the optimization scheme of the phase arrangement of multi-cross universal coupling was presented. The results of test validation and simulation show that the optimization scheme is effective and reasonable. The results of test validation and simulation show that the optimization scheme was effective and reasonable and the optimized scheme could solve the abnormal vibration on floor. Arranging phases of universal joints reasonably is very significative for attenuate the torsional vibration of drive shaft and the floor vibration.