Prototype of a brake-by-wire (BBW) system named Distributed Electro-hydraulic Braking System (DEHB) has been developed. As a BBW system, DEHB is suitable to be used in electric vehicles (EV) and hybrid electric vehicles (HEV). Comparing to the ‘dry’ type distributed BBW systems such as Electro-mechanical Braking System (EMB) or Electric Wedge Brake (EWB), the ‘wet’ feature of DEHB brings benefits to system cost, installation, performance and reliability. In this paper, prototype of the DEHB was described. Based on its ‘wet’ feature, a new fail-safe control for DEHB was proposed. Two types of DEHB architectures that can perform the proposed fail-safe control were described. Superiority of the proposed fail-safe control and architectures for DEHB were examined and verified through simulations and HIL experiments, which helps DEHB to reach a high level of safety and reliability with reduced cost on electro/electronic redundancy.