Dissolved water is a normal component of jet fuel which is vapourised during combustion; however, free water is a contaminant that can starve engines, freeze to form ice crystals capable of blocking fuel feeds, support microbial growth, and contribute towards corrosion.Jet fuel may be protected from the potentially hazardous effects of free-water using biocides and icing/corrosion inhibitors. This investigation seeks to identify novel chemical approaches to the dual management of both water contamination and ice formation in jet fuel.The strategy of using organic molecules as dehydrating agents remains a relatively neglected approach perhaps because of the complexity of the physical organic chemistry involved in developing and refining these systems. However, organic molecules with well characterised dehydrating properties - such as ortho esters, acetals, hemiacetals, ketals, and hemiketals - present themselves as an excellent starting-point for the development and optimisation of novel Fuel Dehydrating Icing Inhibitors (FDII).This paper describes our systematic approach towards the development of jet fuel additives which are kinetically fast, selective, lipophilic water scavengers that produce, upon hydrolysis, a hydrophilic ice inhibitor. A brief human and environmental toxicological screening of candidates is described. We anticipate that this class of FDII represents a novel approach towards protecting jet fuel against the effects of water contamination.