In this work, durability of the bus structure is evaluated with a Virtual Test Model (VTM).Full vehicle Multi Body Dynamics (MBD) model of the bus is built, with inclusion of flexibility of the bus structure to capture structural modes. Component mode synthesis method is used for creation of flexible model for use in MBD.Load extraction is done by performing MBD analysis with measured wheel inputs. Modal Superposition Method (MSM) is employed in FE along with these extracted loads for calculation of modal transient dynamic stress response of the structure. e-N based fatigue life is estimated. The estimated fatigue life from the modal superposition method show good correlation with the physical test results done in 6-poster test rig.