Turbocharger is widely used to boost engine due to emissions, fuel and cost reasons. As one of the hot components, it is subjected to severe temperature and thermal load history. Under these conditions, the material suffers hostile thermal mechanical fatigue (TMF) damage especially for the turbine housing side which absorbs hot exhaust gas directly to drive the turbine wheel. The cracking of turbine housing occurs frequently in the inlet flange location due to its very complex geometry and consequently complicated temperature and stress distribution, seriously affecting the normal operation of the engine. In the electric power industry, one of the most challenging tasks is to ensure the guaranteed lifetime. This paper proposes a novel turbine housing inlet flange design to control this type of failure effectively and improve the component lifetime and reliability. The novel design extends the inlet flange and includes the heat dissipation function as well. It benefits to improve heat transfer condition and reduces thermal stress. Finite element analysis (FEA) as numerical method and laboratory fatigue testing as experimental method have been introduced and applied here for the traditional inlet flange design and the novel design to see the improvement. This novel design in electric power applications is identified successful after validation by both methodologies.