Driver safety is one of the key considerations in truck design and development. Virtual simulation offers opportunities to reduce development time and the number of physical prototypes consumed for design verification and validation for safety parameters. Thus, the application of virtual simulations of crash has become an integral part of the vehicle development process. The continuously emerging scenarios involving challenging test requirements can only be tested by means of virtual simulation techniques.This paper presents simulations that are performed to verify various safety aspects to ensure crashworthiness of the truck cabin. The cabin structure was evaluated for various national/international safety regulations. The FE model and simulation methodology was validated through physical testing and correlated for frontal impact test and roof strength test as per AIS 029/ECE R29. Analysis performed to ensure compliance to upcoming regulation ECE R29 Revision 03 is also discussed. Apart from regulatory requirements, simulations for additional scenarios of full frontal impact and offset impact were carried out to check the performance of the cabin structure. Design features implemented for ensuring safety in the cabs is discussed.