This paper presents an approach to fault detection and isolation that is based on off-board 1D simulation tools such as GT-power or AVL Boost. The proposed method enables engineers to develop diagnostic functions early on in a development project. The proposed algorithm is evaluated based on measurements from the air path system of the new Volvo FH truck. The results are encouraging. The paper discusses pros and cons of the method and concludes that it has clear potential to be used for on-board diagnostics.