In recent trend, there is a huge demand for lightweight chassis frame, which improves fuel efficiency and reduces cost of the vehicle. Stiffness based optimization process is simple and straightforward while durability (life) based optimizations are relatively complex, time consuming due to a two-step (Stress then life) virtual engineering process and complicated loading history. However, durability performances are critical in chassis design, so a process of optimization with simplified approach has been developed. This study talks about the process of chassis frame weight optimization without affecting current durability performance where complex durability load cases are converted to equivalent static loadcases and life targets are cascaded down to simple stress target. Sheet metal gauges and lightening holes are the parameters for optimization studies. The optimization design space is constrained to chassis unique parts. The optimized design is verified for detailed load case and life target. This process helps us in significant weight reduction of 5 % approximately.