In order to meet current and future emission and CO2 targets, an efficient vehicle thermal management system is one of the key factors in conventional as well as in electrified powertrains. Furthermore the increasing number of vehicle configurations leads to a high variability and degrees of freedom in possible system designs and the control thereof, which can only be handled by a comprehensive tool chain of vehicle system simulation and a generic control system architecture.The required model must comprise all relevant systems of the vehicle (control functionality, cooling system, lubrication system, engine, drive train, HV components etc.). For proper prediction with respect to energy consumption all interactions and interdependencies of those systems have to be taken into consideration, i.e. all energy fluxes (mechanical, hydraulically, electrical, thermal) have to be exchanged among the system boundaries accordingly.However, it is very important that the level of detail of the VTMS model fits to the current phase of the vehicle development process. In course of the development process the availability of input data as well as the required engineering targets differ significantly. In order to realize an efficient workflow a seamless modeling environment is essential, which is applicable throughout all phases of the vehicle development.