The suspension system of a heavy truck's driver seat plays an important role to reduce the vibrations transmitted to the seat occupant from the cab floor. Air-spring is widely used in the seat suspension system, for the reason that its spring rate is variable and it can make the seat suspension system keep constant ‘tuned’ frequency compared to the conventional coil spring. In this paper, vibration differential equation of air-spring system with auxiliary volume is derived, according to the theory of thermodynamic, hydrodynamics. The deformation-load static characteristic curves of air-spring is obtained, by using a numerical solution method. Then, the ADAMS model of the heavy truck's driver seat suspension system is built up, based on the structure of the seat and parameters of the air-spring and the shock-absorber. At last, the model is validated by comparing the simulation results and the test results, considering the seat acceleration PSD and RMS value.