This paper first presents an algorithm to detect tire blowout based on wheel speed sensor signals, which either reduces the cost for a TPMS or provides a backup in case it fails, and a tire blowout model considering different tire pressure is also built based on the UniTire model. The vehicle dynamic model uses commercial software CarSim. After detecting tire blowout, the active braking control, based on a 2DOF reference model, determines an optimal correcting yaw moment and the braking forces that slow down and stop the vehicle, based on a linear quadratic regulator. Then the braking force commands are further translated into target pressure command for each wheel cylinder to ensure the target braking forces are generated. Some simulations are conducted to verify the active control strategy. From the simulation results, it is shown that this active brake control strategy can not only ensure the flat tire vehicle stability, but also slow down the vehicle with a safe speed and for a shorter distance.