In this paper, the cyclic deformation behavior of an Al-Si-Cu alloy is studied under strain-controlled thermo-mechanical loading. Tests are carried out at temperatures from 20 °C to 440 °C. The effect of strain rate, hold time at temperature and loading sequence are investigated at each temperature. The results show that temperature has a significant effect on the cyclic deformation of Al-Si-Cu alloys. With increasing temperature, the effect of strain rate and hold time become more significant, while load sequence effects remain negligible within the investigated temperature range. Thus, an elasto-viscoplastic model is required for modeling the alloy's behavior at high temperature. This study provides an insight into the necessary information required for modeling of automotive engine components operating at elevated temperature.