In this paper we consider the issues facing the design of a practical multivariable controller for a diesel engine with dual exhaust gas recirculation (EGR) loops. This engine architecture requires the control of two EGR valves (high pressure and low pressure), an exhaust throttle (ET) and a variable geometry turbocharger (VGT). A systematic approach suitable for production-intent air handling control using Model Predictive Control (MPC) for diesel engines is proposed. Furthermore, the tuning process of the proposed design is outlined. Experimental results for the performance of the proposed design are implemented on a 2.8L light duty diesel engine. Transient data over an LA-4 cycle for the closed loop performance of the controller are included to prove the effectiveness of the proposed design process. The MPC implementation process took a total of 10 days from the start of the data collection to build a calibrated engine model all the way through the calibration of the controller over the transient drive cycle.