In this study, the ignition delay times of DME/n-C4H10 fuel blends (neat DME, 50/50 and neat n-C4H10) diluted with argon were measured behind reflected shock waves. The experiments were performed in the temperature range of 1250 - 1600 K, at pressure of 2.0 MPa and equivalence ratios from 0.5 to 2.0. A latest kinetic mechanism NUIG Aramco Mech 1.3 was validated against the present ignition data and used to conducted chemical kinetic analysis. Different equivalence-ratio-dependent was exhibited at different temperature regimes for DME, n-C4H10, and their blend. Fuel flux analysis, sensitive analysis and mole fraction analysis were carried out for understanding the interaction between the ignition chemistries of DME and n-C4H10.