In this paper, a control approach for the active reduction of engine-induced vibrations in automotive vehicles is presented. As a controller, a discrete-time multiple input multiple output (MIMO) disturbance-observer-based state-feedback controller is designed using linear parameter-varying (LPV) gain-scheduling techniques. The use of LPV control design techniques has the advantage that the stability of the overall system is guaranteed even when the gain-scheduling parameters are changing. The control approach is validated experimentally with an active vibration control system installed in a Golf VI Variant. Two inertia-mass actuators (shakers) and two accelerometers are attached to the engine mounts. Nine frequency components are targeted in the reduction and excellent results are achieved in vehicle driving tests for constant and time-varying engine speeds.