This work analyzes the transmission efficiency of vehicle driveline including the gearbox, universal transmission and differential. Based on the structure of transmission, mathematic models are built to analyze transmission's characteristics. However, an experiment reveals the limitation of this method. Then, the paper statistically analyzes the experimental data and mainly analyzes the influencing factors. Then Neural Network is used to build the efficiency model. A method called “filling data and gradually extrapolating” is used when building neural network model. Finally, the neural network model is used in the simulation of fuel consumption. The conclusion is Neural Network model can imitate the transmission efficiency of vehicle driveline efficiently, but its internal structure is not clear so other modeling methods are needed to be found.