Managing ISO 26262 software development projects is a challenging task. This paper discusses major challenges in managing safety-critical projects from a high-level perspective, i.e. from a manager's point of view. We address managers (directors) with full project responsibility including software and hardware teams. Rather than discussing how to fulfill (technical) requirements stated by the ISO standard, we highlight major challenges and tough decisions a manager has to face on her way from project start up to delivery of the safety case.We discuss important project management topics and best practices such as negotiation issues with the contractor (OEM), selection of the appropriate functional safety manager, general ISO 262626-related project management matters, as well as contractual issues with supplier such as development interface agreement. We discuss the topics on the basis of real-life experience we collected during several ISO 26262 management projects.