This paper describes a CAE fatigue life prediction technique for a tailgate on pickup truck cargo box with inertial forces and moments applied at mass center of the tailgate as input loads. The inertial forces and moments are calculated from the accelerations measured at the corners of the tailgate as the truck is being driven over a durability schedule at the test proving grounds. All the dynamic responses of the tailgate on cargo box, including any dynamic interactions at the pivot joints between the tailgate and box sides, are captured in the acquired data and also in the inertial forces and moments computed at the mass center. Correspondingly, all the dynamic responses are included in the CAE fatigue life predictions. The dynamic interactions at the pivot joints are simulated by using two identical CAE models, one with lateral translational constraint applied at the left pivot only and the other at the right pivot only. The final fatigue damages of the tailgate are the average damages from the two models.With this technique, the CAE fatigue life predictions correlated to test results well in both low fatigue life locations and magnitudes.