With improvements in casting technology, cast iron can be an alternative to steel in some applications due to its similar strength. One objective of this study was to analyze cast iron data obtained from the literature and evaluate predictive correlations between its tensile, microstructural, and fatigue properties. Reasonably good correlation of tensile strength and yield strength were found with hardness. However, fatigue strength could not be correlated with hardness or tensile properties. Another objective of this study was to evaluate tensile and compressive means stress effects on fatigue behavior of 120-90-02 ductile cast iron experimentally, as well as analytically by using predictive models. Mean stress levels were chosen such that R ratios in load-controlled tests were −7, −3, −1, 0, 1/3, 0.5, and 0.75. Modified Goodman, Smith-Watson-Topper, FKM and the Fatemi-Socie mean stress parameters were used to account for the mean stress effect on fatigue life. Constant life diagrams were also constructed to evaluate predictive capabilities of these mean stress models for applications in design.