In order to reduce automobile body weight and improve crashworthiness, the use of high-strength steels has increased greatly in recent years. An optimal combination of both crash safety performance and lightweight structure has been a major challenge in automobile body engineering. In this study, the Cockcroft-Latham fracture criterion was applied to predict the fracture of high-strength steels. Marciniak-type biaxial stretching tests for high-strength steels were performed to measure the material constant of the Cockcroft-Latham fracture criterion. Furthermore, in order to improve the simulation accuracy, local anisotropic parameters based on the plastic strain (strain dependent model of anisotropy) were measured using the digital image grid method and were incorporated into Hill's anisotropic yield condition by the authors. In order to confirm the validity of the Cockcroft-Latham fracture criterion, uniaxial tensile tests were performed. It was found that the accuracy of the predicted rupture strain was improved if the local anisotropic r-value was used. To predict failure and force-stroke curve in collision phenomena, the Cockcroft-Latham fracture criterion, considering the local anisotropic r-value, was applied to three-point bending tests. The simulated results showed that the fracture locus of hat-shaped section and force-stroke curves were accurately predicted.