The vehicle ride comfort behavior is closely associated with the vibration isolation system such as the primary suspension system, the engine mounting system, the cab suspension system and the seat suspension system. Air spring is widely used in the cab suspension system for its low vibration transmissibility, variable spring rate and inexpensive automatic leveling.The mathematical model of the air spring is presented. The amplitude and frequency dependency of the air spring's stiffness characteristic is highlighted. The air spring dynamic model is validated by comparing the results of the experiment and the simulation. The co-simulation method of ADAMS and AMESim is applied to integrate the air spring mathematical model into the cab multi-body dynamic model. The simulation and ride comfort test results under random excitation are compared. It shows that the co-simulation model of the cab air spring suspensions which considers the effects of the air spring dynamic stiffness characteristic has a good agreement with that in the test.