The EcoCAR 2: Plugging into the Future team at The Ohio State University is designing a Parallel-Series Plug-in Hybrid Electric Vehicle capable of 44 miles of all-electric range. The vehicle features an 18.9-kWh lithium-ion battery pack with range extending operation in both series and parallel modes. This is made possible by a 1.8-L ethanol (E85) engine and 6-speed automated manual transmission. This vehicle is designed to drastically reduce fuel consumption, with a utility factor weighted fuel economy of 50 miles per gallon gasoline equivalent (mpgge), while meeting Tier II Bin 5 emissions standards. This paper details three years of modeling and simulation development for the OSU EcoCAR 2 vehicle. Included in this paper are the processes for developing simulation platform and model requirements, plant model and soft ECU development, test development and validation, automated regression testing, and controls and calibration optimization. This effort was made possible through the generous support from the U.S. Department of Energy, General Motors, The Ohio State University, and numerous competition and team sponsors.