An experimental study has been carried out with the end goal of minimizing engine-out methane emissions with Premixed Micro Pilot Combustion (PMPC) in a natural gas-diesel Dual-Fuel™ engine. The test engine used is a heavy-duty single cylinder engine with high pressure common rail diesel injection as well as port fuel injection of natural gas. Multiple variables were examined, including injection timings, exhaust gas recirculation (EGR) percentages, and rail pressure for diesel, conventional Dual-Fuel, and PMPC Dual-Fuel combustion modes. The responses investigated were pressure rise rate, engine-out emissions, heat release and indicated specific fuel consumption. PMPC reduces methane slip when compared to conventional Dual-Fuel and improves emissions and fuel efficiency at the expense of higher cylinder pressure.